Mumps virus decreases testosterone production and gamma interferon-induced protein 10 secretion by human leydig cells.
نویسندگان
چکیده
Mumps virus is responsible for sterility. Here, we show that the mumps virus infects Leydig cells in vitro and totally inhibits testosterone secretion and that ribavirin in mumps virus-infected Leydig cell cultures completely restores testosterone production. Moreover, we show that gamma interferon-induced protein 10 (IP-10) is highly expressed by mumps virus-infected Leydig cells and that ribavirin does not block IP-10 production.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of virology
دوره 77 5 شماره
صفحات -
تاریخ انتشار 2003